Sections:
2900-001: Fall 2014 – September 29, 2014 – February 21, 2015
2900-002: Winter 2015 – January 12 – May 23, 2015
2900-003: Spring 2014 – April 13 2015 – July 25, 2015
NOTE: Students registered in this course must access the online lectures via The UofT Portal. This requires a UTORID. Your UTORID will be provided for you by e-mail a week before the course starts. Kindly register in time to start the course on the first day.
|
Assigned Lecture Number |
Topic |
Instructor |
|
1A |
Introduction to SCS2900 |
Profs. Arnot and Laposa |
| 1B | Introduction to Pharmacology | |
|
2 |
What is a drug? |
Prof. Ross |
| Interview I: Importance of New Drug Development, Prof. Ross | Prof. Arnot | |
|
3 |
Drugs as molecules |
Prof. Ross |
|
4 |
Overview of Pharmacokinetics and Physiology Concepts |
Prof. Burnham |
|
5 |
Route of Administration |
Prof. Burnham |
|
Clinical Vignette #1 |
Formulations |
Dr. Shear |
|
6 |
Mechanism of Drug Absorption |
Prof. Burnham |
|
7 |
Drug Distribution I |
Prof. Burnham |
|
8 |
Drug Distribution II |
Prof. Burnham |
| 9 |
Introduction to Clearance and Biotransformation |
Prof. Burnham |
|
Clinical Vignette #2 |
Anaesthetics |
Dr. Shear |
|
10 |
Biotransformation I |
Prof. Burnham |
|
11 |
Biotransformation II |
Prof. Burnham |
|
|
Visit #1: Tyndale Laboratory |
|
|
12 |
Total Body Clearance |
Prof. Burnham |
|
13 |
Organ Clearance |
Prof. Burnham |
|
14 |
Clinical Pharmacokinetics |
Prof. Burnham |
|
Clinical Vignette #3 |
What is Clinical Pharmacology? |
Dr Shear |
|
15 |
Introduction to Pharmacodynamics |
Prof. Ross |
|
16 |
Drug–Receptor Interactions |
Prof. Ross |
|
|
Visit #2: Ramsey/Salahpour Laboratory | |
|
17 |
Drug Classification I – Agonist |
Prof. Ross |
|
18 |
Drug Classification II – Antagonists and Partial Agonists |
Prof. Ross |
|
19 |
Receptor Diversity & Enzymes as Targets |
Prof. Ross |
|
20 |
Enzyme Targets II: ASA & NSAIDS |
Prof. Ross |
|
21 |
Enzyme Targets III: ACE-Inhibitiors and ACHase Inhibitors |
Prof. Ross |
|
22 |
Enzyme Targets IV: Antibiotics |
Prof. Ross |
| Clinical Vignette #4 | HIV – AIDS Drug Therapy | Dr. Shear |
|
23 |
GPCR I: Introduction |
Dr George |
|
24 |
GPCR II: Drugs that Modulate |
Dr George |
|
25 |
GPCR III: Quirks and Quarks of Receptor Signaling |
Dr. George |
| Clinical Vignette #5 | Clinical Agents that Target GPCRs | Dr. George |
| 26 | Drugs that Target: GC & PDE | Prof. Ross |
|
27 |
Tyrosine Kinase Receptors I |
Prof. Ross |
|
28 |
Tyrosine Kinase Receptors II: Pharmacology |
Prof. Ross |
|
29 |
Drug Transporters as Drug Targets |
Prof. Grant |
|
Interview II: Importance of Drug Transporters, Dr. Piquette-Miller |
||
|
30 |
Membrane Physiology and Ion Channels |
Prof. Grant |
|
31 |
VGIC I: Structure and Function |
Prof. Grant |
|
32 |
VGIC II: Modulation |
Prof. Grant |
|
33 |
LGIC I: Nicotinic Ach Receptors |
Prof. Grant |
|
34 |
LGIC II: GABA-A and Glutamate Receptors |
Prof. Grant |
|
Clinical Vignette #6 |
Muscle Relaxants |
Dr Shear |
|
35 |
Nuclear Receptors I |
Prof. Grant |
|
36 |
Nuclear Receptors II: Steroid Hormone |
Prof. Grant |
|
37 |
Nuclear Receptors III: Non-Steroids |
Prof. Grant |
|
Clinical Vignette #7 |
Environmental Factors and Genes | Dr. Shear |
|
38 |
Genes as Targets |
Prof. Grant |
|
39 |
Immunopharmacology |
Prof. Grant |
|
40 |
Drug Variability |
Prof. Grant |
|
41 |
Pharmacogenetics |
Prof. Grant |
| Interview III: Application of PGx, Dr. Tyndale | ||
|
42 |
Drug-Drug Interactions |
Prof. Grant |
|
43 |
Adverse Drug Reactions |
Prof. Grant |
|
Clinical Vignette #8 |
Geriatric Pharmacology |
Dr Shear |
|
44 |
Introduction to Toxicology |
Prof. Grant |
|
45 |
Teratogenesis |
Prof. Grant |
|
46 |
Perinatal Pharmacology |
Prof. Grant |
|
Visit #3: Motherisk at Sick Childrens Hospital, Dr. Gideon Koren |
|
|
|
47 |
Drug Misuse |
Prof. Ross |
|
|
Interview #3 – History of Drug Misuse, Dr Harold Kalant |
Prof. Ross |
|
48 |
Natural and Herbal Compounds in Performance and Therapeutics |
Prof. Ross |
|
49 |
Drugs in Sports |
Prof. Ross |
|
50 |
Review |
Prof. Ross |
|
51 |
Wrap Up |
Profs. Arnot & Laposa |
| EXAM: Organized by School of Graduate Studies |